Her Filipino mother Concepcion Garina is from Sipalay City, Negros Occidental,[3] and her father James Peter Dodd was a White American retired senior officer of the US state department.
[5] In 2010, Ramirez auditioned for Star Magic with the song "Angels Brought Me Here" by Guy Sebastian, and was accepted, with her first project with ABS-CBN being teen variety show Shoutout!
In 2015, Ramirez starred as Michelle Gutierrez in a series of episodes in ABS-CBN's Wansapanataym, followed by a special participation in the Nasaan Ka Nang Kailangan Kita remake of the film of the same name.
Ramirez gained further popularity after joining the second half (Book 2) of the teleserye Pangako Sa 'Yo (2015) as Joy "Ligaya" Miranda, the "third wheel" of the show's primary "love team" Yna Macaspac (Kathryn Bernardo) and Angelo Buenavista (Daniel Padilla).
[11] In 2016, Ramirez was given the role of Angel (Serena's biological sister played by Liza Soberano) in Dolce Amore and topbilled the viral story of Genesis, a Filipino artist who sold his paintings for a mother who suffered from severe illness in Maalaala Mo Kaya – Paru-paro.
[8] In the last quarter of 2017, Sue Ramirez led the cast of the horror movie The Debutantes together with Miles Ocampo, Michelle Vito, Jane de Leon and Chanel Morales.
She joined the Main Cast of the Philippine television drama series Hanggang Saan with veteran actress Sylvia Sanchez became part of the 2017 Metro Manila Film Festival entry Meant to Beh: Ika-something na Utos with Vic Sotto and Dawn Zulueta.
In 2022, she portrayed Lexy Lucero, a woman in a relationship with a married man, in the Kapamilya teleserye The Broken Marriage Vow as main antagonist, which began airing in January 2022.
[6] In the same year, she appeared in The Iron Heart as Venus Magbanua, the leading lady of Richard Gutierrez who works with him previously in La Luna Sangre.