Sulfluramid (N-EtFOSA) is a chemical compound from the group of sulfonic acid amides and per- and polyfluoroalkyl substances (PFASs) that is effective as an insecticide.

It acts as an uncoupler (IRAC group 13).

Annual production increased from about 30 tons in 2003 to 60 tons in 2013.

[1] It is predominantly biotransformed to perfluorooctanesulfonic acid (PFOS),[2] but partly also to perfluorooctanoic acid (PFOA).

[3][4] Sulfluramid has been banned for almost all insecticidal applications; the only use still allowed by annex B of the Stockholm Convention on Persistent Organic Pollutants is a bait to control leaf-cutting ants.