[2] In 1497, together with his Timurid cousin Babur, he besieged Samarkand for seven months and conquered the city .
When Babur was abandoned by his troops and returned to Andijan in 1498, Sultan Ali Mirza seized the Samarkand throne.
According to sources, a representative of the nobility, Muhammad Mazid Tarkhan, was the real master in Samarkand.
He gave all important positions to his sons and followers and controlled the finances of the city.
In 1500, Samarkand capitulated to Muhammad Shaybani, Khan of the Uzbeks, and Sultan Ali Mirza was executed.