In 1496, he was forced to fight to retain power against his brother, Sultan Ali Mirza.
Initially, he was supported by Sultans Mahdi and Hamza, who were close to the Uzbek Khan Muhammad Shaybani, but later they abandoned him.
He subsequently lost Bukhara to his brother Sultan Ali Mirza.
[1] In 1499, Khusroe Shah planned a campaign against Balkh, and asked Sultan Baysunkar Mirza to join him.
When they reached the Aubaj river crossing on 17 August 1499, Khusroe Shah attacked Baysunkar and strangled him with a bowstring.