As a pioneer of single-molecule biophysical chemistry, Coherent Raman scattering microscopy, and single-cell genomics, he made major contributions to the emergence of these fields.

Furthermore, he has made significant advances on medical applications of label-free optical imaging and single-cell genomics.

In particular, his inventions in single-cell genomics have been used in in vitro fertilization benefited thousands of families by avoiding the transmission of monogenic diseases to their newborns.

More than fifty of his students and post-doctorates have become professors at major universities around the world, and two are co-founders of start-up companies.

Professor Xie’s current research interests include the following scientific, technological, and medical areas: