It is the second game in the Pang series and was ported to the Super Nintendo Entertainment System in 1992.

The object of the game is to take the role as Buster (P1) or Kutch (P2) to use their guns to pop bubbles that bounce around the screen.

Panic mode is beaten when the player reaches level 99, fills the rainbow bar and destroys any remaining bubbles on the screen (after the bar is filled and level 99 is reached, no new bubbles appear).

In the SNES version, there are four difficulty levels in the arcade mode: easy, normal, hard and expert.

The amount of continues and general speed of bubbles is also affected by the difficulty level chosen.

In Japan, Game Machine listed Super Buster Bros. on their January 1, 1991 issue as being the eight most-successful table arcade unit of the month, outperforming titles such as Carrier Air Wing and Columns.