The Regency has an area of 634.24 km2 including the Aruri Islands group to the south, and had a population of 15,874 at the 2010 Census[2] and 22,547 at the 2020 Census;[3] the official estimate as at mid 2023 was 24,013 - comprising 12,434 males and 11,579 females.

[1] Until 8 January 2004, this area was part of the Biak Numfor Regency, from which it was split off in accordance with the Law (Undang-Undang RI No.35 Tahun 2003) dated 18 December 2003.

Its West Supiori District also includes Mapia Atoll to the northwest, approximately 290 kilometers north of the city of Manokwari.

[1] The table also includes the administrative centre of each district, the number of administrative villages (all classed as kampung) and of minor islands within each district, and its post code.

Sorendiweri, the seat of the regency has a tropical rainforest climate (Af) with heavy rainfall year-round.