[14] In September 2023, Lee said that her office would consider removing former President Donald Trump from the primary election ballot under the Fourteenth Amendment.

These meetings resulted in the Senate Judicial Proceedings Committee releasing a report with 19 recommendations to help the state's correctional systems navigate the COVID-19 pandemic.

[20] In March 2021, Lee rebuked disparaging statements made by former president Donald Trump regarding the COVID-19 pandemic, in which phrases like "Kung Flu" and the "China virus" stoked racism toward Asian communities.

[21][22] Later that month, after CNN aired a clip showing senior Hogan health advisor and then-Centers for Disease Control and Prevention director Robert R. Redfield saying he believed the COVID-19 virus "escaped" from a lab in China in September or October 2019, Lee took to the floor of the Maryland Senate to condemn Redfield's comments and suggested that Asian-Americans could be targeted because of his remarks.

[23][24] During the 2020 legislative session, Lee introduced a bill that would require prosecutors to disclose whether facial recognition or DNA profiling were used during the criminal investigation of a case.

[26] During the 2021 legislative session, Lee introduced a bill that would repeal the prohibition on prosecuting sexual crimes against a victim who is the spouse of the assailant.

[31] The bill was reintroduced during the 2022 legislative session,[32] during which it passed the House of Delegates and the state Senate, and became law without Governor Hogan's signature.

[33][34] Following the bill's passage, she was invited to the White House by U.S. President Joe Biden,[34] where he announced a new United States Department of Justice rule regulating privately made firearms.

[35] During the 2020 legislative session, Lee introduced a bill that would require background checks for private sales of long guns.

[39] In June 2018, following national outcry about the Trump administration's family separation policy, Lee called on Maryland counties to "stop taking blood money from ICE" to detain immigrants.

[40] In April 2015, Lee endorsed U.S. Representative Chris Van Hollen in the 2016 United States Senate election in Maryland.