She earned a scholarship and extra income from helping in her mother's eatery for her studies towards a bachelor's degree in journalism at Lyceum of the Philippines University.

[6] Her first TV appearance was met with criticism from the audience for her lack of makeup and messy hair, a practice she said that was not required during her radio stint.

[5][13] The show's format centered on Filipino identity, folklore, beliefs, and cuisine and earned the Anak TV Seal on the same year it premiered.

On October 22, 2012, she hosted GMA News TV's morning show Kape at Balita together with Joel Reyes Zobel, Mariz Umali, and Michael Fajatin.

[5] Aside from iJuander, Enriquez is currently serving as the host of Pera Paraan since it premiered on July 22, 2020, via GMA News TV.

[22] On March 20, 2023, Enriquez replaces Emil Sumangil as one of the hosts in the news magazine program, Dapat Alam Mo!

[12] Ricky Lo of The Philippine Star wrote, "Since she is in our consciousness seemingly every hour on the hour from early morning to sometimes late at night when she pinch-hits for colleagues on leave, Susan Enriquez has become every household’s lovable companion who proves that big things indeed come in small packages.

"[7] B. Allie Tah of Rappler also said, "Through the years, she has been consistent with her public persona as a warm and simple TV personality with a comprehensive, no-nonsense dedication in her trade of broadcast journalism.

She is an accommodating news personality, especially among housewives who approach her for consumer problems, domestic concerns and barangay issues.