[2] Her father, Seymour Solomon, was the co-founder of Vanguard Records alongside his brother, Maynard;[2][3] her mother, Ruth (Katz), was a pianist and worked as a manager of concert musicians.

She was the founder and President of Sony Worldwide Networks,[7] the chairman and CEO of Lancit Media Productions,[2] an Emmy award-winning television production company, and then served as the founding CEO of Sotheby's website[8] prior to founding her own strategic management consulting firm Solomon Partners LLC in 2000.

[2] Solomon was a founding Board member of the Global Alliance for iPSC Therapies (GAiT) and New Yorkers for the Advancement of Medical Research (NYAMR).

[13] As a result of her son's diagnosis and then her mother's death from cancer in 2004, she sought to find a way in which the most advanced medical research could translate more quickly into cures.

In conversations with clinicians and scientists, Solomon identified stem cells as the most promising way to address unmet patient needs.