[6] After completing her PhD, Margulies joined the Mayo Clinic as a postdoctoral researcher working in a pulmonary lab.
[10] By studying the molecular biology of injured cells, Margulies hopes to develop therapeutic measures for traumatic injury.
[13] In May 2017 she was announced as Chair of the Coulter Department and Eminent Scholar at Emory University and the Georgia Institute of Technology.
[15][16] In 2020 Margulies was elected to the National Academy of Engineering for elaborating the traumatic injury thresholds of brain and lung in terms of structure-function mechanisms.
[17] The same year she was also elected to the National Academy of Medicine for identifying how and why injuries occur in children's brains and lungs through the development and use of novel platform technologies and models, and for translating basic discoveries of three therapies in pre-clinical trials.