[1] Following a failed marriage that same year to Nelson Meriman, after which he left her destitute with a child, she followed Charlotte's advice to pursue an acting career with her.
On December 30, 1845, at the Haymarket in London, they were so successful in playing Romeo and Juliet,[2] respectively, (using the original version as opposed to theatre prompt) before an audience who labeled them as "American Indians", that they continued there for eighty nights before touring England.
Although Charlotte, who enjoyed playing masculine roles, was a good showman and received acclaim from critics, they also praised Susan for the "grace and delicacy of her acting".
Sheridan Knowles commended Charlotte primarily, but, in regards to Susan, lauded the first act as being "admirably personated by her beautiful sister".
When Susan walked in late during the manager's audition of a replacement actress, an angry scene developed which, by Mrs. Mowatt's account, was "such as I never before, and I rejoice to say never after, witnessed in a theatre".