[5] She worked as Google's first marketing manager in 1999, leading the company's online advertising business and original video service.

[11] Her paternal grandmother, Janina Wójcicka Hoskins, was a Polish-American librarian at the Library of Congress and was responsible for building the largest collection of Polish material in the U.S.[12] She had two sisters: Janet, a doctor of anthropology and epidemiology,[13] and Anne, an entrepreneur who is the co-founder and CEO of 23andMe.

[16] She also received her MS in economics in 1993 from the University of California, Santa Cruz, and an MBA in 1998 from the UCLA Anderson School of Management.

[21] Wojcicki was introduced to the pair through a mutual friend around the time she was newly married and struggling to afford the mortgage on her recent house purchase.

[40] Wojcicki also emphasized new YouTube applications and experiences designed to cater to users interested in family[41] gaming,[42] and music[43] content.

While CEO, the company developed 10 forms of monetization for YouTube creators, including channel memberships, merchandise, BrandConnect, and paid digital goods like Super Chat.

[46] In 2020, the company launched YouTube Shorts, its short-form video experience,[47] which surpassed 50 billion daily views in February 2023.

[53] YouTube has also faced criticism that the company applies its enforcement policies inconsistently, with larger content creators treated more favorably.

She said she wanted to focus on "family, health, and personal projects" but would be taking on an advisory role across Google and its parent company Alphabet.

[61] She also owned a real estate holding company that worked on the sustainable growth of Los Altos, California.

[63] Wojcicki married Dennis Troper, a director of product management at Google, in Belmont, California, on August 23, 1998.

[66][58][67] On February 13, 2024, Wojcicki's son Marco Troper, a 19-year-old student at the University of California, Berkeley,[68][69] died of acute combined drug toxicity.

[71][72][73][74] In November 2024, three months after her death, a final message prepared by Wojcicki was publicly released where she reflected on her career, highlighting the significance of creativity, collaboration, and adhering to core values in leadership.