After graduating from high school in 1996, she studied classical singing at the Hochschule für Musik Freiburg until 2001.
[1] She interpreted different musical styles such as jazz, funk, rock and soul.
After her acting training, which she graduated with a diploma in 2007, she was seen in 2010 in Forsthaus Falkenau and in 2011 in Der Doc und die Hexe.
In addition, she repeatedly had episode roles in SOKO München and the Die Rosenheim-Cops.
Since 2017, Padotzke has played the main role of the pathologist Caroline Fuchs in the ARD early evening series Hubert ohne Staller.