Wilks' TV career began on the Nine Network, replacing Tracey Dale on the lifestyle series Our House in February 1998.
She was recruited to host Changing Rooms, an Australian version of the very successful BBC lifestyle program of the same name, which premiered on the Nine Network in September 1998; that year Wilks became the first woman to host two prime-time shows on Australian television in the same year.
After an eight-year run on Changing Rooms, Wilks resigned and returned to her home town, Melbourne.
Since Wilks' time on Changing Rooms she has accepted invitations to various celebrity events and TV programs.
She also won her episode of the 2008 series The Singing Bee and made two appearances on Network Ten's game show Thank God You're Here.
[1][better source needed] Wilks appeared in TV and press advertisements for Holden cars and Cadbury chocolates.