It flows east past Desborough and the Eleanor cross at Geddington, then through the grounds of Rushton Hall,[1] before turning south and passing through the parkland of Boughton House where it was extensively canalised and landscaped in the late 17th century.

[2] It then flows between Kettering and Barton Seagrave where its valley was excavated during the creation of Wicksteed Park to provide a large lake for public amenity use.

The Ise contains many varieties of coarse and game fish, including roach, perch, barbel, rudd, common dace and chub.

The Slade Brook sub-catchment is the largest tributary of the Ise and drains much of the urban area of Kettering, as well as smaller settlements west of the town including Rothwell and Broughton.

[6] In both the upper and lower Ise, the predominant factor preventing the rivers from achieving "Good" status under the framework is high levels of phosphate, derived from poor nutrient and livestock management in the surrounding agricultural land and continuous discharge of treated sewage effluent.