The men's 100m freestyle S5 event at the 2012 Summer Paralympics took place at the London Aquatics Centre on 8 September.

There were two heats; the swimmers with the eight fastest times advanced to the final.

'Q = qualified for final.

AS = Asian Record.

Official London 2012 Paralympics Results: Heats Archived 2013-01-27 at archive.today Official London 2012 Paralympics Results: Final Archived 2013-01-29 at archive.today