The Men's 100 metre freestyle S4 event at the 2016 Paralympic Games took place on 8 September 2016, at the Olympic Aquatics Stadium.

Two heats were held.

The swimmers with the eight fastest times advanced to the final.

10:32 8 September 2016:[1] 10:37 8 September 2016:[1] 18:33 8 September 2016:[2]