The women's 100 metre butterfly S8 event at the 2016 Paralympic Games took place on 9 September 2016, at the Olympic Aquatics Stadium.

Two heats were held.

The swimmers with the eight fastest times advanced to the final.

11:26 9 September 2016:[1] 11:30 9 September 2016:[1] 20:22 9 September 2016:[2]