The Women's 100 metre freestyle swimming events for the 2020 Summer Paralympics took place at the Tokyo Aquatics Centre from 26 August to 3 September 2021.
The final in this classification took place on 30 August 2021: The S5 category is for swimmers who have hemiplegia, paraplegia or short stature.
The final in this classification took place on 31 August 2021: The S9 category is for swimmers who have joint restrictions in one leg, or double below-the-knee amputations.
The final in this classification took place on 31 August 2021: The S10 category is for swimmers who have minor physical impairments, for example, loss of one hand.
The final in this classification took place on 28 August 2021: The S11 category is for swimmers who have severe visual impairments and have very low or no light perception, such as blindness; they are required to wear blackened goggles to compete.