The route runs through the Sylamore Ranger District of the Ozark National Forest in Arkansas for 26.5 miles (42.6 km) in Stone County.

[1] It passes through undeveloped forest land as a scenic route to Blanchard Springs Caverns.

The Sylamore Scenic Byway begins at the National Forest Service Blanchard Springs Caverns Visitor Center.

The Sylamore Creek Byway begins an overlap with Highway 5 and Highway 9 northbound, following the White River and passing the Miles Jeffery Barn.

It passes through Optimus, an unincorporated community, before terminating at a bridge over the White River.