A second segment of 19.23 miles (30.95 km) runs from Highway 140 in Lepanto east to Mississippi CR S449 at Golden Lake.

As the road approaches Main Street in Omaha, Highway 14 turns east and exits the city.

Highway 14 continues south past the Slippery Hollow Natural Area, a preserved area of caves serving as habitat the Ozark big-eared bat and other endangered species[5] and the unincorporated community of Lakeway before a junction with another segment of Highway 125.

[6] Highway 14 curves eastward, entering the small town of Summit from the north and becomes Main Street.

Now designated Panther Avenue, the road passes Yellville–Summit High School and Central Ozarks Medical Center before curving through a residential section of town and intersecting US 62 and US 412 in downtown Yellville.

The three routes form a concurrency eastbound along Main Street, passing through the historic commercial center of Yellville, including the Marion County Courthouse.

US 62/US 412/Highway 14 bridge the East Prong Town Branch before Highway 14 turns south, ending the concurrency.

[6] Highway 14 passes through the northeast corner of Searcy County; a sparsely populated part of the Ozark Mountains.

Highway 14 joins the concurrency southbound into Mountain View, with the Sylamore Scenic Byway turning north toward Calico Rock.

The two routes serve a commercial area of the city, including the Mountain View Airport, Sylamore Ranger District Office of the Ozark National Forest, Mountain View High School, and the Stone County Medical Center before Highway 5 turns south, ending the concurrency.

[11] Highway 14 continues eastbound through rural Stone County, passing through sparsely populated and forested Ozarks hills, serving as the western terminus for Highway 58 before beginning a stretch passing several historic properties listed on the National Register of Historic Places: the John Bettis House in Pleasant Grove,[12] and six properties in Marcella, including: the H.J.

Within the city, Highway 14 serves as Main Street[21] and passes the historic Hankins' Store before exiting eastbound.

Together they span the White River and the Union Pacific Railroad tracks before turning sharply onto Third Street and running downtown.

The highway continues east through sparsely populated agricultural lands, crossing the L'Anguille River before entering the county seat of Harrisburg.

The route begins at Highway 140 in Lepanto and runs east into Mississippi County as a section line road through sparsely populated agricultural areas.

Arkansas Highway 14Y (AR 14Y) is an unsigned connector route of 0.31 miles (0.50 km) in Jackson County.