Sylvestre Mudingayi (11 November 1912 – 23 December 1983) was a Congolese politician who served as the President of the Senate of the Democratic Republic of the Congo from October 1965 until June 1967.

Sylvestre Mudingayi was born on 11 November 1912 in Lusambo, Kasai Province, Belgian Congo[1] to a Luba family.

[4] Mudingayi was classified by Christian missionaries as a "socialist" due to his advocacy for the establishment of secular schools.

[7] While campaigning for the PNP in the Luputa region of Kasai in March for the upcoming elections, he was assaulted by opposing political activists.

[7] In September 1965 Mudingayi was elected President of the Senate as a member of the Front Démocratique Congolais (FDC) in a surprise victory over the incumbent, Isaac Kalonji, 57 votes to 54.