Sylvia's interest in medical reporting came when she worked at KPRC-TV in Houston, where she also became the weekend co-anchor of ChannelTwoNews.
Perez was also the station's "Healthbeat" reporter covering daily health and medical investigative stories for the 4:00 p.m. and 10:00 p.m. newscasts.
There she followed an Illinois veteran back to Hawaii to visit the USS Arizona where his brother and many other American war heroes died when the harbor was attacked.
On June 20, 2013, Sylvia was released from WLS-TV after 24 years with the station because they decided to cancel the 11:00 a.m. newscast.
In September 2016, media critic Robert Feder announced on his blog that Perez had been hired to anchor the weekend morning newscasts on WFLD-TV.