[1][2] Though King Manuel I of Portugal ordered the forced conversion or expulsion of Portuguese Jews in 1496, Marranos continued using the synagogue as a religious sanctuary and school until the mid 16th century.

[1][2] Since April 2019, the building has housed a small museum dedicated to Castelo de Vide's historical Jewish community.

[1][2] The structure is listed as a Building of Public Interest (Imóvel de Interesse Público) by the Portuguese government.

The synagogue is a small two-story building originally constructed in the late 14th century and altered over time.

[1][2] Inside the building exists a 15th-century carved stone Torah ark or tabernacle (referred to as a hekhal by Sephardic communities) which was rediscovered in 1972 during repairs to the exterior walls.