Synodontis woleuensis is a species of upside-down catfish native to Equatorial Guinea and Gabon.

[3] The specific name "woleuensis" is derived from the Woleu River, where the specimens were originally collected.

[3] The body of the fish is dark brown, with a variable pattern and number of light, cream-colored spots.

[2] The caudal fin has a narrow, light-colored curved band along the anterior margin.

[1] Specimens have been found in the Woleau River of Gabon and Equatorial Guinea, and the Kyé River that runs along the border between Equatorial Guinea and Gabon.