Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers.

Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients.

[7] The PDZ domain of syntrophin-α1(SNTA1), the most abundant isoform in the heart, has been reported to bind to the C-terminal domain of murine cardiac voltage-gated sodium channels (SkM2) causing altering ion channel activity leading to Long QT syndrome.

[8][9] Syntrophin, alpha 1 has been shown to interact with Dystrophin,[5][10][11] Nav1.1[11] and Nav1.5,[11] and Aquaporin 4.

This article on a gene on human chromosome 20 is a stub.