The Syracuse and Binghamton Railroad was established on August 18, 1851, and opened for business on October 18, 1854.

[3] In 1853, the company was consolidated with the Oswego and Syracuse Railroad after the act was authorized by the New York State Legislature.

The company had a machine shop West of Clinton Street near the "Regimental" Armory.

[2] By December 1888, directors of the company included Samuel Sloan, Percy R. Pyne, George Bliss, Uriel A. Murdock, Frederick H. Gibbens, Fred F. Chambers, Benjamin G. Clark, Moses Taylor Pyne, Edgar S. Auchinclose, E. R. Holden and W. S. Sloan, all of New York City.

Samuel Sloan was president of the company, Fred F. Chambers was secretary and Frederick H. Gibbens was treasurer.