Systematic Protein Investigative Research Environment (SPIRE) provides web-based experiment-specific mass spectrometry (MS) proteomics analysis in order to identify proteins and peptides, and label-free expression and relative expression analyses.
SPIRE provides a web-interface and generates results in both interactive and simple data formats.
Tandem, OMSSA and SpectraST SPIRE can produce an increase in protein IDs (50-90%) over current combinations of scoring and single search engines while also providing accurate multi-faceted error estimation.
SPIRE also connects results to publicly available proteomics data through its Multi-Omics Profiling Expression Database (MOPED).
SPIRE can provide analysis and annotation for user-supplied protein ID and expression data.