Tiruvengimalai Sesha Sundara Rajan (1880–1953) was an Indian medical doctor, politician and freedom-fighter who served the Minister of Public Health and Religious Endowments in the Madras Presidency from 1937 to 1939.

Rajan was born in Srirangam in Trichinopoly district and studied medicine at Royapuram Medical School, Madras and England.

He served as the President of the Tamil Nadu Congress Committee and as the Member of the Imperial Legislative Council of India from 1934 to 1936.

He had his early education from St. Joseph's College, Trichinopoly and graduated in medicine from Royapuram Medical School, Madras.

[1] During his days in England, Rajan was a close associate of V. D. Savarkar and V. V. S. Aiyar and was a member of the India House.

[7] In 1934, Rajan was elected to the Imperial Legislative Council of India and served till 1936, when he resigned owing to differences of opinion.

[1] In 1946, when the Congress was elected to power once again in Madras Presidency and Tanguturi Prakasam became Premier, Rajan was appointed Minister of Food and Public Health.