2MAE, 2MVK, 2MVL407056753ENSG00000184292ENSMUSG00000051397P09758Q8BGV3NM_002353NM_020047NP_002344NP_064431Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1)[5] is a protein that in humans is encoded by the TACSTD2 gene.

It transduces an intracellular calcium signal and acts as a cell surface receptor.

Later, its expression was also described in the normal stratified squamous epithelium of the skin, uterine cervix, esophagus, and tonsillar crypts.

Trop-2 expression has also been described in some rare and aggressive malignancies, e.g., salivary duct, anaplastic thyroid, uterine/ovarian, and neuroendocrine prostate cancers.

These facts make Trop-2 a possible prognostic biomarker to identify high-risk patients, as well as an attractive therapeutic target for late-stage diseases[9] This antigen is the target of sacituzumab govitecan and datopotamab deruxtecan (Dato-DXd),[11] both antibody-drug conjugates.