[5][6] The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.

ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).

The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble.

Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.

[7] TAP1 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.