Though related to CL-20 in that is shares the same cage structure, TEX is more easily synthesized in good yield from inexpensive starting materials.

Unlike CL-20, which requires a cumbersome and even costly procedure, TEX is obtained in moderate yield (40 wt.-%) in a one-pot synthesis from 1,4-diformyl-2,3,5,6-tetrahydroxypiperazine (DFTHP) and mixed acid (H2SO4/HNO3).

However, in comparison to insensitive explosive NTO, which is highly soluble in water (16 g/L), it should pose a lower level of concern when considering the environmental effects of unexploded or partially exploded charges.

Preliminary investigation of the effects of TEX on daphnia and cell cultures show slightly lower toxicity than RDX.

However, given its large critical diameter and low shock sensitivity, it is an ideal candidate for insensitive large-calibre ammunition such as general-purpose bombs, artillery shells, torpedoes and depth charges.