Studies suggest TGFB1I1 plays a role in processes of cell growth, proliferation,[7] migration, differentiation[8] and senescence.

[7][10][11] Transforming growth factor beta-1-induced transcript 1 plays a role in a number of cell functions.

Originally, TGFB1I1 was isolated as a senescence-inducing gene from mouse osteoblastic cells through treatment with transforming growth factor beta-1 and hydrogen peroxide.

[9] During this, TGFB1I1 was also being independently discovered by numerous other groups and was characterized as a focal adhesion protein,[12][13] an androgen and glucocorticoid receptor co-activator,[10][14] a negative regulator of muscle differentiation,[8] and major player in the recovery of arterial media.

[15][16] TGFB1I1 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.