5J8R578219248ENSG00000127947ENSMUSG00000028771Q05209P35831NM_001131008NM_001131009NM_002835NM_011203NM_001356590NM_001356591NM_001356592NP_001124480NP_001124481NP_002826NP_035333NP_001343519NP_001343520NP_001343521Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

This PTP contains a C-terminal PEST motif, which serves as a protein–protein interaction domain, and may be related to protein intracellular half-life.

This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis.

This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.