[5][6] This gene encodes an RGD-containing protein that binds to type I, II and IV collagens.

The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins.

This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage.

The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.