1XU1, 1XUT2349557916ENSG00000240505ENSMUSG00000010142O14836Q9ET35NM_012452NM_021349NP_036584NP_067324Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) is a protein that in humans is encoded by the TNFRSF13B gene.

TNFRSF13B is a transmembrane protein of the TNF receptor superfamily found predominantly on the surface of B cells, which are an important part of the immune system.

TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL).

Defects in the function of TACI can lead to immune system diseases and has shown to cause fatal autoimmunity in mice.

[10][11] This article incorporates text from the United States National Library of Medicine, which is in the public domain.