4HT1874221944ENSG00000239697ENSMUSG00000097328O43508O54907NM_003809NM_011614NP_003800NP_035744Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein that in humans is encoded by the TNFSF12 gene.

[5] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family.

This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution.

Leukocytes are the main source of TWEAK including human resting and activated monocytes, dendritic cells and natural killer cells.

This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.