The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family.

This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM).

[6] This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus.

[10] This protein is also reported to prevent tumor necrosis factor alpha-mediated apoptosis in primary hepatocytes.

[7] This article incorporates text from the United States National Library of Medicine, which is in the public domain.