1BSX, 1N46, 1NAX, 1NQ0, 1NQ1, 1NQ2, 1NUO, 1Q4X, 1R6G, 1XZX, 1Y0X, 2J4A, 2NLL, 2PIN, 3D57, 3GWS, 3IMY, 3JZC, 4ZO1706821834ENSG00000151090ENSMUSG00000021779P10828P37242NM_001354709NM_001354710NM_001354711NM_001354712NM_001354713NM_001354714NM_001354715NM_001374822NM_001374823NM_001374824NM_001374825NM_001374826NM_001374827NM_001113417NM_009380NP_001341638NP_001341639NP_001341640NP_001341641NP_001341642NP_001341643NP_001341644NP_001361751NP_001361752NP_001361753NP_001361754NP_001361755NP_001361756NP_001106888NP_033406Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene.

[5][6] The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine (T3).

Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone.

Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).

[7] Thyroid hormone receptor beta has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.