The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes.

The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis.

In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation.

This pathway facilitates reverse topology budding and formation of multivesicular bodies (MVB) which delivers cargo destined for degradation to the lysosomes.

The additional domains and motifs extending beyond the core serve as gripping tools for ESCRT-I critical functions.