[5] This gene encodes a member of the family of pyridine nucleotide oxidoreductases.

This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress.

Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity.

The selenocysteine is encoded by the UGA codon that normally signals translation termination.

[6] This article incorporates text from the United States National Library of Medicine, which is in the public domain.