[16][17] Throughout training camp, Sharpe competed with Andre Johnson, Dorial Green-Beckham, and Kendall Wright for a starting wide receiver position.

[18] During a Week 10 47–25 victory over the Green Bay Packers, Sharpe caught three passes for 68 yards and his first NFL touchdown on a 33-yard reception from Marcus Mariota in the third quarter.

[19] In the next game against the Indianapolis Colts, Sharpe had four receptions for 68 yards and a 34-yard touchdown pass as the Titans lost on the road by a score of 24–17.

[26] Sharpe returned from his injury in time for the Titans' season-opening 27–20 road loss to the Miami Dolphins, recording a 17-yard reception.

[27] Three weeks later against the Philadelphia Eagles, Sharpe had three receptions for 27 yards and his first touchdown of the season as the Titans won by a score of 26–23 in overtime.

[32] During a Week 7 23–20 victory over the Chargers, Sharpe had two receptions for 19 yards and his first touchdown of the season on a five-yard pass from Ryan Tannehill.

[33] In the next game against the Tampa Bay Buccaneers, Sharpe recorded three receptions for 18 yards and a touchdown as the Titans won by a score of 27–23.

[37] The Titans finished with a fourth straight 9–7 season, qualifying for the playoffs and advancing to the AFC Championship Game where they lost to the eventual Super Bowl Champions, the Kansas City Chiefs.

[50] After head coach Matt Eberflus announced that Sharpe would miss the whole 2022 season with a rib injury,[51] he was placed on injured reserve on August 31, 2022.

Dante R. Satterfield, the plaintiff in the lawsuit, claims he told Sharpe he'd probably lose playing time as a result of the Titans selecting wide receiver Corey Davis in the first round.

Satterfield claims he was knocked unconscious for 12 hours, suffered a concussion, and facial fractures from the incident and is suing for $500,000 in damages.