During the civil war in Tajikistan, Iran offered to mediate between the two factions; however, these efforts did not produce any negotiations.

[3] On February 12, 2011, Tajik Foreign Minister Hamrokhon Zarifi, at an event in Dushanbe celebrating the anniversary of Iran's Islamic Revolution, stated: "Today, Tajik society is witnessing the Islamic Republic of Iran's activity and role in the growth and expansion of Tajikistan's economy."

Babak Zanjani was charged with money laundry, embezzlement and stealing over six billion dollars from Iranian oil and gas industry.

Iran being under American sanctions and economic hard time saw this belligerent action by a friendly ally as a betrayal and a sign to reduce further commercial ties and industrial collaborations with Tajikistan.

Revival of the Silk Road in the form of highways connecting China, Tajikistan, Afghanistan and Iran has been a major focus of the two governments.

[7] The two sides engage in the following energy and infrastructural projects: Anzob Tunnel, Sangtuda-2 Hydroelectric Power Plant and the Rogun Dam.