While Italian writer Angiolello and Iranian historian Manuchihr Parsaʹdust agree that she was a granddaughter of the Aq Qoyunlu ruler Yaqub (r. 1478–1490) via a daughter, John Woods proposed her paternal lineage as Mihmad Beg being her father and Amir Hamza being her grandfather.
[3] According to Angiolello and Ramusio, the Safavid shah Ismail I (r. 1501–1524) married Tajlu Khanum after defeating the Aq Qoyunlu ruler Murad ibn Ya'qub in 1503, but according to the Safavid-period historians such as Budaq Monshi Qazvini, she was the wife of the Afrasiyabid ruler Kiya Husayn II, who had during the dissolution of the Aq Qoyunlu confederation expanded his rule from western Mazandaran into parts of Persian Iraq.
She was a very beautiful, intelligent, and warlike woman, which is why Shah Ismail loved her and wrote great poems for her.
Her supposed capture at Battle of Chaldiran was a major source of controversy among historians of Iran and Ottoman Empire.
Tajlu financed shrine of Fatima al-Masuma in Qom in 1519, supported Tahmasp Mirza's elevation to throne in 1524.