As a four-year-old in 2013 he won the Alysheba Stakes but later that summer suffered a condylar fracture in the Monmouth Cup, which required surgery, but ended his racing career and his owners, WinStar Farm, retired him to stud.
Indy won the Belmont Stakes and the Breeders' Cup Classic in 1992 before going on to become a successful breeding stallion: his other progeny include Bernardini, Friesan Fire, Mineshaft, Pulpit and Rags to Riches.
In October, Take Charge Indy competed at Grade I level for the first time in the Dixiana Breeders' Futurity at Keeneland and finished fourth of the thirteen runners behind Dullahan.
The colt did not race again for months, with Byrne controversially withdrawing his charge from the Tampa Bay Derby after receiving an unfavorable outside draw.
[8] Take Charge Indy reappeared in the Grade I Florida Derby at Gulfstream and started at odds of 7.7/1 for a race in which his rivals included Union Rags (the 2/5 favorite) and El Padrino.
[4] After five and a half months off the track, Take Charge Indy returned to action on October 27 in the Grade II Fayette Stakes over a mile and one eighth at Keeneland, where he was matched against older horses for the first time.
[11] Take Charge Indy began his third season in the Grade I Donn Handicap at Gulfstream on February 9, 2013 when he finished third, beaten eight lengths by the Graydar, who led from the start.
[13] On June 16, Take Charge Indy was made favorite for the Stephen Foster Handicap but after racing in second place he faded in the closing stages and finished last of the six runners behind Fort Larned.
[14] Following a successful operation at the Hogan Equine clinic, where three screws where inserted into the horse's leg, it was announced that Take Charge Indy had been retired and would begin stallion duties at WinStar in 2014.