The campaign takes place primarily in the then-future of 2013, on a 3,800 square kilometer section of Seattle, Washington and its surrounding metropolitan area.

[3] In the campaign mode, the player takes on the role of a civilian helicopter pilot, Tom Larkin, whose civil aviation business is struggling through hard times.

The campaign also features flashback missions, where the player takes on the role of Larkin's older brother, Joe Larkin, during his military service as a U.S. Army helicopter pilot during a 2012 war in Takistan, the fictional country that was the setting of Bohemia Interactive's 2010 video game, ARMA 2: Operation Arrowhead.

[5] In addition to the career, the game includes challenges, time trials, training, a mission editor, free flight, and multiplayer.

[6] Take On Helicopters is set in two large open world terrains (North American and South Asia) based upon real-world terrain-data.