Talat studied with Hafiz Mirzaliyev and Firuz Alizadeh at the Azerbaijan National Conservatory Music College named after Asaf Zeynally in 1947–1949.

Since 1947 he was a soloist of the Azerbaijan State Academic Philharmonic Hall named after Muslim Magomayev.

Talat Bakikhanov performed not only within Azerbaijan, but also in France, Indonesia, Malta, Iran, Iraq, Turkey, Syria.

So in the film "If Not That One, Then This One", based on the musical comedy of the same name by the Azerbaijani composer Uzeyir Hajibeyov, Talat Bakikhanov accompanies Khan Shushinski.

Talat Bakikhanov participated in the first and second international symposia held in Samarkand in the 1970s and 1980s, where he presented Azerbaijani Mugham with such masters as Bahram Mansurov, Alim Gasimov.