Throughout most of the 1800s the area now considered Tallulah-North Shore consisted mainly of farms, lumberyards and naval stores operations.

In 1879, anticipating residential growth in the region, a man by the name of Jeremiah Fallausbee platted an area he called Tallulah.

The corner of N. Pearl Street and Tallulah Avenue is the commercial area most associated with the Tallulah-North Shore neighborhood.

Currently the home of Miller's Soulfood Kitchen, the intersection's most striking building was designed by local architect Taylor Hardwick as a milk house for the Skinner's Dairy company.

[2] The neighborhood's eastern border is made up exclusively of commercial development paralleling Main Street (US 17).

These routes include the following:[4] North Shore Park is located along the Trout River at the northern terminus of Pearl Street.

The park contains picnic facilities, a boat landing, an asphalt walking trail and stone benches.