A branch of the family continued to rule Khairpur, under British suzerainty and later as a Pakistani princely state, until 1955 when it was amalgamated into West Pakistan.

Another relative, Mir Thara Khan, established the Mankani branch in southeast Sindh around the area around Mirpur Khas - a city which was founded by his son Ali Murad Talpur.

[citation needed] The Talpur brothers extended their rule over neighbouring regions such as Balochistan, Kutch, and Sabzalkot, covering an area of over 100,000 square kilometers, with a population of approximately 4 million.

During their rule, Syed Ahmad Barelvi tried to garner support for a campaign against the Sikh emperor Ranjit Singh, but was perceived to be a British agent.

The British conquered Karachi in 1839, and with the support of Khojas and Hindus, were able to quickly advance on Hyderabad, forcing the Talpurs to pay tribute.

Seth Naumal, a Hindu merchant, was held responsible by the Talpurs for encouraging non Baloch tribes in lower Sindh to defect and aid the British.

These replicas were built for the poor people who did not have resources to travel to the actual shrines in Iraq and Iran, and continue to operate until present day.

[14] The Talpur dynasty was established in 1783 by Mir Fateh Ali Khan, who declared himself the first Rais, or ruler of Sindh, after defeating the Kalhoras at the Battle of Halani.

[citation needed] The Talpur dynasty was established in 1783 by Mir Fateh Ali Khan, who declared himself the first Rais, or ruler of Sindh, after defeating the Kalhoras at the Battle of Halani.

During the 1857 Sepoy Mutiny, Ali Murad sided which the British, and prevented rebels from seizing the Shikarpur jail and treasury.

The Khairpur government instituted a council of regency under local ministers and ordered the Mir to live outside the state.

After a period of twelve years, and shortly before the transfer of power, he abdicated in favour of his minor son George Ali Murad Khan in July 1947.

[16] Mir Sher Muhammad Talpur established friendly relations with the Sikh emperor Ranjit Singh, but fought against the British.

"[17] Mirpur Khas remained the capital of the Talpur Mirs of Mirpurkhas until 1843, when Sindh was annexed to British India under the East India Company following the conquest of Sindh by Charles James Napier and defeat of Mir Sher Muhammad Talpur on 24 March 1843 at the battleground of Dubbo.

The conference commenced with the Presidential address by Mir Ali Nawaz Khan Talpur, the ruler of Khairpur State, in which he called on the Baloch for unity.